Integrated Drug Discovery Service
Our experienced research teams can help achieve the following:
Compound design and synthesis to improve potency and selectivity.
Develop structure activity relationships (SAR).
Chemistry service
Organic synthesis
ZB CHEM provides the following types of discovery chemistry services
- Custom Synthesis (> 95% purity, milligrams to kilograms scale)
- Designed compounds for SAR studies
- Reference compounds
- Building blocks & scaffolds
- Key and advanced intermediates
- Synthetic pathway design, evaluation and scouting
Medicinal chemistry
ZB CHEM provides the following types of discovery chemistry services
- Active assessment
Synthesis and confirmation of actives
- Active-to-hit exploration
- Novelty assessment
- Competitor analysis
- Lead optimization
- SAR development
Process chemistry R&D
- Route evaluation and development of new synthetic routes for target molecules.
- Optimization of reaction conditions to reduce cost and maximize throughput
- Development of reliable methods for in-process testing and analysis of intermediates and API’s.
- Scale-up of existing routes in jacketed glass reactors (30-100 L) and fixed reactors (up to 1000 L capacity)
- Performance of work under cryogenic conditions (-78 °C)
- Assessment of critical process parameter
- Development and transfer of analytical methods
- Kilo lab / Pilot plant manufacturing APIs & Intermediates under GMP or cGMP.
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